Analysis of NDE1 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-2472-LGZ)

Introduction

Official Full Name: nudE neurodevelopment protein 1<br />Also known as: NDE; LIS4; MHAC; NUDE; NUDE1; HOM-TES-87<br />This gene encodes a member of the nuclear distributed E (NudE) protein family. The encoded protein localizes to the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an important role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause anencephaly, a disorder characterized by anencephaly, severe brain shrinkage, microcephaly and severe cognitive impairment. Alternative splicing results in multiple transcript variants.