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Official Full Name: NLR family pyrin domain containing 6
Also known as: AVR; NAVR; PAN3; NALP6; PYPAF5; CLR11.4; NAVR/AVR
The protein encoded by this gene binds arginine-vasopressin and may be involved in the regulation of arginine-vasopressin-mediated renal saline balance. The encoded protein also mediates the inflammatory response of the colon, allows recovery of intestinal epithelial damage, and prevents tumorigenesis and the development of colitis. Finally, this protein can increase NF-kappa-B activation, CASP1 activation, and cAMP accumulation through the interaction with ASC. Two transcript variants of this gene have been found to encode different isoforms.