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Also known as: NS6; CMNS; KRAS; NCMS; ALPS4; N-ras; NRAS1
This is an N-ras oncogene that encodes a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated by palmitoylation and depalmitoylation of the ZDHHC9-GOLGA7 complex. The encoded protein has intrinsic GTPase activity, is activated by guanine nucleotide exchange factors, and is inactivated by GTPase activating proteins. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myeloid leukemia.