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Official Full Name: NUF2 component of NDC80 kinetochore complex
Also known as: CDCA1; CT106; NUF2R
The gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with centromeres. Yeast Nuf2 disappears from the centromere when it loses its connection to the spindle pole body during meiotic prophase and plays a regulatory role in chromosome segregation The encoded protein was found to be associated with the centromeres of mitotic HeLa cells, suggesting that this protein is a functional homologue of yeast Nuf2. Alternative splice transcript variants encoding the same protein have been described.