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Also known as: GAMOS8; NPHS18; hNUP133
In eukaryotic cells, the nuclear membrane forms distinct nuclear and cytoplasmic compartments. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form water channels to regulate the flow of macromolecules between the nucleus and cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin encoded by this gene exhibits evolutionarily conserved interactions with other nucleoporins. The protein localizes to both sides of the interphase nuclear pore complex, maintains association with the complex during mitosis, and targets the reorganized nuclear membrane during early stages. This protein is also localized to the centromere of mitotic cells.