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Osteopontin (OPN) is a glycosylated protein widely present in the extracellular matrix. It was initially thought that OPN is an important bone matrix protein, which is closely related to the formation and development of bone. Studies have shown that the activity of osteopontin (OPN active protein) can directly reach the intestinal tract, enhance the protective barrier function of the intestinal tract, realize systemic immune protection, and reduce 50% of biological functions such as fever and discomfort.