Analysis of OX40L/TNFSF4 (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0475-LGZ)

Introduction

OX40 binds to the ligand OX40L (CD252, TNFSF4) to transmit co-stimulatory signals. The OX40 gene is located on chromosome 1 in humans and mice and encodes a 34kD transmembrane glycoprotein type II. OX40L can be expressed on antigen-presenting cells (APCs), such as B cells, dendritic cells and macrophages. In addition, expression can be induced in other cell types such as Langerhans cells, endothelial cells, smooth muscle cells, mast cells, and NK cells.