Analysis of PDGFR-β (total) (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0486-LGZ)

Introduction

Platelet derived growth factor (PDGF) is an alkaline protein stored in platelet α particles. It is a low molecular weight cytokinin. It can stimulate fibroblasts, glial cells, smooth muscle cells and other cells stuck in G0/G1 phase to enter the cycle of division and proliferation. Platelet-derived growth factor PDGF is a peptide regulatory factor that stimulates the growth of connective tissue and other tissue cells discovered in 1974. It is named for its origin in platelets. It exists in the α granules of platelets under normal physiological conditions and is released and activated by disintegrating platelets when blood coagulates. PDGF has the biological activity of stimulating specific cell chemotaxis and promoting specific cell growth. In addition, macrophages, vascular smooth muscle cells, fibroblasts, endothelial cells and embryonic stem cells can also synthesize and release PDGF when tissues are damaged. PDGF can be secreted by macrophages, platelets, infiltrating inflammatory cells, damaged endothelial cells and activated hepatic astrocytes when liver is damaged. It acts in an autocrine or paracrine manner. The binding PDGF is A thermostable glycoprotein with molecular weight of 30KD, which is a dimer formed by the combination of two polypeptide chains A and B connected by disulfide bond.