Unlock Exclusive Discounts & Flash Sales! Click Here to Join the Deals on Every Wednesday!
Official Full Name: platelet derived growth factor receptor alpha<br />Also known as: CD140A; PDGFR2; PDGFR-2<br />This gene encodes a cell surface tyrosine kinase receptor for a member of the platelet-derived growth factor family. These growth factors are mitogens for mesenchymal cells. The identity of the growth factor bound to the receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, consisting of platelet-derived growth factor receptor alpha and beta polypeptides. Studies have shown that the gene plays a role in organ development, wound healing and tumor progression. Mutations in this gene are associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.