Analysis of PIAS3 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0576-LGZ)

Introduction

Official Full Name: protein inhibitor of activated STAT 3<br />Also known as: ZMIZ5<br />This gene encodes a member of the PIAS (Inhibitor of Activating STAT (Signal Transducer and Activator of Transcription) Proteins) family of transcriptional regulators. This protein acts as a SUMO (Small Ubiquitin-like Modifier)-E3 ligase, catalyzing the covalent attachment of SUMO proteins to specific target substrates. It directly binds to several transcription factors, blocking or enhancing their activity. Alternative splicing transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined.