Analysis of PLA2G4A Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0568-LGZ)

Introduction

Official Full Name: phospholipase A2 group IVA
Also known as: GURDP; cPLA2; PLA2G4; cPLA2-alpha
This gene encodes a member of the group IV family of cytoplasmic phospholipase A2. This enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid, which is subsequently metabolized to eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cytokines that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids, which are converted to platelet-activating factor. The enzyme is activated by elevated intracellular Ca(2+) levels and phosphorylation, leading to its translocation from the cytoplasm and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants.