Analysis of PPP1R15B Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0594-LGZ)

Introduction

Official Full Name: protein phosphatase 1 regulatory subunit 15B<br />Also known as: CREP; MSSGM2<br />This gene encodes a protein phosphatase I interacting protein that promotes dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under cellular stress conditions. The transcribed messenger RNA contains two upstream open reading frames (ORFs), which under normal conditions repress the translation of proteins mainly encoding ORFs, which are expressed at high levels in response to stress. Ongoing translation of mRNA under conditions of inactivation of eukaryotic translation initiation factor 2A is thought to create a feedback loop for gene reactivation during stress recovery. Furthermore, this protein has been shown to play a translation-independent role in membrane trafficking and is required for exocytosis in erythroleukemic cells. Allelic variation in this gene has been associated with microcephaly, short stature, and impaired glucose metabolism.