Analysis of PR/PGR (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0497-LGZ)

Introduction

The PR/PGR gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events related to the establishment and maintenance of pregnancy. This gene uses two distinct promoters and translation initiation sites in the first exon to generate several transcript variants, both protein-coding and non-protein-coding. The two isoforms (A and B) are identical except for an additional 165 amino acids found at the N-terminus of the B isoform, which regulate their own response genes and physiological effects with little overlap.