Analysis of PSMA1 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-2409-LGZ)

Introduction

Official Full Name: proteasome 20S subunit alpha 1
Also known as: NU; HC2; PROS30; HEL-S-275
The proteasome is a multicatalytic protease complex with a highly ordered ring-shaped 20S core structure. The core structure consists of 4 rings of 28 different subunits; 2 rings of 7 α subunits and 2 rings of 7 β subunits. The proteasome is distributed in high concentrations in eukaryotic cells and cleaves peptides in a non-lysosomal pathway in an ATP/ubiquitin-dependent process. A modified proteasome, the essential function of the immunoproteasome is to process MHC class I peptides. This gene encodes a member of the T1A family of peptidases, the 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding different isoforms.