Analysis of PSMD13 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-2112-LGZ)

Introduction

Official Full Name: proteasome 26S subunit, non-ATPase 13<br />Also known as: S11; Rpn9; p40.5; HSPC027<br />The 26S proteasome is a multicatalytic protease complex with a highly ordered structure consisting of 2 complexes, a 20S core and a 19S regulator. The 20S core consists of 4 rings composed of 28 different subunits; 2 rings composed of 7 α subunits, and 2 rings composed of 7 β subunits. The 19S regulator consists of a base (containing 6 ATPase subunits and 2 non-ATPase subunits) and a lid (containing up to 10 non-ATPase subunits). The proteasome is distributed in high concentrations in eukaryotic cells and cleaves peptides in a non-lysosomal pathway in an ATP/ubiquitin-dependent process. A modified proteasome, the essential function of the immunoproteasome is to process MHC class I peptides. This gene encodes the non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described.