Unlock Exclusive Discounts & Flash Sales! Click Here to Join the Deals on Every Wednesday!
Advanced glycation end product receptor (RAGE) is a 35kDa immunoglobular superfamily transmembrane receptor that derives its name from its ability to bind to advanced glycation end products. RAGE is generally considered a class of recognition receptors because of its inflammatory function in innate immunity and its ability to recognize a class of ligand by a common motif. Compared with other tissues, RAGE was most expressed in the lungs, especially in type I alveolar epithelial cells, but not in idiopathic pulmonary fibrosis (IPF), suggesting that the expression and regulation of RAGE in the lung system is different from that in the cardiovascular system. Blocking/knocking out RAGE resulted in impaired cell adhesion and increased cell proliferation and migration.