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RANTES/CCL5 (regulated upon activation, expressed and secreted in T cells) is a member of the "C-C" or beta chemokine family that induces inflammation and has been implicated in a variety of inflammatory diseases. RANTES is primarily produced and secreted by CD8+ T cells, macrophages, platelets, epithelial cells, fibroblasts, and certain tumor cells. RANTES is a chemoattractant with additional regulatory functions on a variety of cell types including monocytes, memory T cells, natural killer cells, eosinophils, basophils, dendritic cells and mast cells.