Analysis of RHOC Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1164-LGZ)

Introduction

Official Full Name: ras homolog family member C<br />Also known as: H9; ARH9; ARHC; RHOH9<br />This gene encodes a member of the Rho family of small GTPases that cycles between inactive and active GTP-bound states and acts as a molecular switch in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton, regulating cell shape, attachment and motility. The protein encoded by this gene is pentylated at its C-terminus and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell movement. The overexpression of this gene is related to the proliferation and metastasis of tumor cells. Multiple alternative splice variants encoding the same protein have been identified.