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S100 calcium-binding protein A8 (S100A8), also known as calgranulin A (CAGA), is a protein encoded by the S100A8 gene and is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs. It and S100A9 form a heterodimer called calprotectin. It is mainly derived from immune cells such as neutrophils and macrophages. There is some evidence that it can inhibit the precipitation of calcium oxalate in the environment of urine samples at its subphysiological concentrations. It may also function in the body as an inhibitor of calcium oxalate kidney stone formation. It also has antimicrobial potential due to its ability to bind zinc. It plays an important role in protecting the body from pathogenic infections, and its overexpression amplifies the inflammatory response, accelerating the release of more cytokines from neutrophils and macrophages, thereby inducing a vicious cycle and exacerbating the disease.