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Also known as: AFD1; Hsh49; SAP49; SF3b49
This gene encodes one of the four subunits of splicing factor 3B. The protein encoded by this gene cross-links to the pre-mRNA region upstream of the pre-mRNA branch point sequence of the A pre-spliceosome complex, which may also be involved in the assembly of the B, C, and E spliceosome complexes. In addition to RNA-binding activity, this protein also directly and highly specifically interacts with subunit 2 of splicing factor 3B. The protein contains two N-terminal RNA recognition motifs (RRMs), consistent with the observation that it directly binds to pre-mRNAs.