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Official Full Name: ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
Also known as: IV; SIAT3C; SIAT7D; SIAT3-C; SIAT7-D; ST6GalNAc; ST6GALNACIV
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from cmp-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and displays limited substrate specificity, utilizing only the trisaccharide sequence neu5ac-α-2,3-gal-β-1,3-galnac. In addition, it is also involved in the synthesis of ganglioside GD1A by GM1B. The encoded protein is normally found in the Golgi apparatus, but can be proteolytically processed to a soluble form. This protein is a member of the glycosyltransferase family 29. Transcript variants of this gene have been found to encode different isoforms. Readable transcripts exist for this gene and the downstream ST6GALNAC6 gene.