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Official Full Name: transforming growth factor beta 2<br />Also known as: LDS4; G-TSF; TGF-beta2<br />This gene encodes a secreted ligand for the tgf-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-β receptors, leading to the recruitment and activation of SMAD family transcription factors, which regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-β family members. Disruption of the TGF-β/SMAD pathway is associated with a variety of human cancers. Chromosomal translocations that include this gene have been associated with Peters anomaly, a congenital defect of the anterior chamber. Mutations in this gene may be associated with Lois-Dietz syndrome. This gene encodes multiple isoforms that likely undergo similar proteolytic processes.