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Official Full Name: TNF receptor superfamily member 11b
Also known as: OPG; TR1; OCIF; PDB5
The protein encoded by this gene is a member of the TNF receptor superfamily. This protein is a decoy receptor secreted by osteoblasts and functions as a negative regulator of bone resorption. This protein specifically binds its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of mouse counterparts have also shown that this protein and its ligands play a role in lymph node organogenesis and vascular calcification. An alternatively spliced transcript variant of this gene has been reported, but its full-length nature has not been determined.