Analysis of TNFRSF18 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1230-LGZ)

Introduction

Official Full Name: TNF receptor superfamily member 18<br />Also known as: AITR; GITR; CD357; GITR-D; ENERGEN<br />This gene encodes a member of the TNF receptor superfamily. The encoded receptor has been shown to increase expression upon T cell activation and is thought to play a key role in the maintenance of dominant immune self-tolerance by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest a role for this receptor in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants encoding different isoforms of this gene have been reported.