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Official Full Name: TNF receptor superfamily member 1B
Also known as: p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II
The protein encoded by this gene is a member of the TNF receptor superfamily. This protein forms a heterocomplex with TNF receptor 1, mediating the recruitment of two anti-apoptotic proteins c-IAP1 and c-IAP2 with E3 ubiquitin ligase activity. The function of IAPs in TNF receptor signaling is unclear, however, c-IAP1 is thought to enhance TNF-induced apoptosis by mediating the ubiquitination and degradation of TNF receptor-associated factor 2, an anti-apoptotic signal. Knockout studies in mice also showed that the protein protects neurons from apoptosis by stimulating antioxidant pathways.