Analysis of Transferrin/TF by ELISA (CAT#: STEM-MB-1576-LGZ)

Introduction

Transferrin (TF) is a secreted protein, belonging to the transferrin family, which is expressed by liver and secreted into plasma. TF has a molecular weight of about 80kDa and contains two specific high affinity Fe3+ binding sites. TFs is an iron-binding glycoprotein in plasma that regulates the level of free iron in biological fluids. Its main role is to transport iron from duodenal absorption centers and leukocyte macrophages to other tissues. TF is associated with the innate immune system. In an inflammatory state, its levels are reduced. It is common to see increased plasma TF levels in patients with iron deficiency anemia. Plasma TF levels are generally reduced in patients with iron overload and protein dystrophy. More recently, TF and its receptors have been found to reduce tumor cells when TF receptors attract antibodies. TF is an acute phase protein, so its levels are decreased in inflammation, cancer, and certain diseases.