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Also known as: IRF; SMRZ; MURF1; MURF2; RNF28<br />This gene encodes a member of the RING family of zinc finger proteins found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z- and M-line lattices of myofibrils. This protein plays an important role in atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain proteins, myosin binding protein and muscle creatine kinase.