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Official Full Name: thioredoxin interacting protein
Also known as: THIF; VDUP1; ARRDC6; HHCPA78; EST01027
This gene encodes a thioredoxin-binding protein, a member of the alpha-arrestin family. Thioredoxin, a thiol oxidoreductase, is a master regulator of cellular redox signaling, protecting cells from oxidative stress. This protein inhibits the antioxidant function of thioredoxin, leading to the accumulation of reactive oxygen species and cellular stress. The protein also regulates cellular metabolism and endoplasmic reticulum stress. This protein also acts as a tumor suppressor. Alternate splicing results in multiple transcript variants.