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The Wnt family has multiple secreted glycoproteins that play important roles in animal development. There are 19 Wnt genes in the human genome, which can encode Wnt proteins with different functions. Wnt members bind the Frizzled receptor family of seven transmembrane proteins and activate multiple signal transduction pathways. Aberrant activation of the Wnt signaling pathway is associated with various cancer types. The Wnt3a protein is palmitoylated and acts as a growth factor for hematopoietic stem cells.