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Interleukin-5 acts as a homodimer, and is essential for maturation of eosinophils in the bone marrow and their release into the blood. In humans, interleukin-5 acts only on eosinophils and basophils, in which it causes maturation, growth, activation, and survival. In addition, the anti-IL-5 therapies are biologically active and significantly reduce blood and sputum eosinophils and symptomatic exacerbations in patients with severe asthma.