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c-Myb is a transcriptional activator that binds with a dissociation constant of about 10 -9 M to the specific DNA sequence PyAACG/TG, where Py indicates a pyrimidine. The DNA-binding domain (DBD) of c-Myb consists of three imperfect 51 or 52 residue repeats (designated RI, R2, and R3 from the N-terminus), and the last two repeats, R2 and R3, are the minimum unit for specific DNA binding. The NMR structure of the complex of the minimum DBD (R2R3) with the Myb-binding DNA sequence (MBS-I) revealed that each third helix in R2 and R3 is engaged in direct and specific base recognition.