Biomolecular Screening and Lead Discovery Service Based on 600 MHz Spectrometer

STEMart offers a dedicated Biomolecular Screening and Lead Discovery Service using high-resolution 600 MHz spectrometers, including the Bruker Avance Neo 600 MHz and JEOL ECZ600R 600 MHz systems. These advanced instruments enable high-sensitivity NMR screening, crucial for identifying potential drug candidates and understanding biomolecular interactions. Our screening and lead discovery services are designed to accelerate drug development by providing detailed data on target binding, molecular affinities, and structural information.

Our 600 MHz NMR spectrometers employ principles of nuclear magnetic resonance to detect even subtle binding interactions between biomolecules and potential drug candidates. Through techniques such as ligand-detected and protein-detected NMR, we can study the interaction dynamics, affinity ranking, and structural features of lead compounds. This service is widely used in drug discovery and molecular biology to identify and characterize new therapeutic candidates with high precision.

Leveraging our advanced NMR technology, STEMart offers comprehensive biomolecular screening services, including binding affinity measurement, fragment-based screening, and structural characterization. Our services provide researchers with accurate, high-quality data essential for identifying and optimizing lead compounds in early-stage drug development.

What We Offer

• Binding Affinity Measurement

Provides precise quantification of binding affinity between drug candidates and target biomolecules, supporting prioritization of high-affinity leads.

• Fragment-Based Screening

Screens small molecular fragments for binding potential, identifying initial hits that can be optimized into lead compounds.

• Structural Characterization of Leads

Determines the structural details of lead compounds bound to target molecules, aiding in drug design and optimization.

• Competitive Binding Studies

Examines competitive binding interactions, enabling researchers to identify binding site preferences and competitive dynamics.

Why Choose Us

• High Sensitivity for Weak Interactions

Our 600 MHz spectrometers are optimized for detecting even low-affinity interactions, crucial in the early stages of drug discovery.

• Experienced Drug Discovery Specialists

Our team of experts in biomolecular NMR ensures reliable data interpretation, supporting effective lead identification and optimization.

• Flexible and Detailed Reporting

We provide customizable reports that meet specific project needs, ensuring clarity and actionable insights in data presentation.

• Non-Destructive Screening Process

Our NMR screening preserves sample integrity, allowing for further analysis or additional screening if required.

Our Resources

Bruker Avance Neo 600 MHz NMR

The Bruker Avance Neo 600 MHz spectrometer, equipped with advanced Cryoprobe technology, provides high sensitivity and resolution for screening and lead discovery applications. Its capabilities enable accurate binding studies and molecular screening essential for drug development research.

JEOL ECZ600R 600 MHz NMR

This JEOL 600 MHz system offers reliable performance for biomolecular screening, with precision suitable for fragment-based screening and structural characterization. Its robust design supports complex screening studies, making it invaluable for early drug discovery.

STEMart provides high-quality NMR services tailored to meet the specific needs of our clients. Our experienced specialists use advanced equipment and follow strict quality control measures to ensure accurate and reliable results. Contact us to learn more about our NMR services and how we can help you achieve your research goals.