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Negative thermal ionization mass spectrometry (NTIMS) is an effective and robust analytical method which allows to analyze the boron isotopic composition (δ11B) of natural waters directly with an analytical uncertainty of ± 0.5‰ (2σm, corresponding to 2σ/n0.5, where n = 3 − 8 replicate analyses), determined by analysis of a large number (N = 70) of natural fresh and saline waters.