C Subfamily Detection Service (CAT#: STEM-MB-0261-WXH)

Introduction

Chemokines are a class of factors or signaling proteins secreted by cells. They are called chemokines because they have the ability to induce directional movement of nearby responding cells. Existing studies have found that chemokines have four cysteine residues in their conserved positions. These residues are very important for the formation of spatial structure of chemokines. Therefore, according to the different distribution of these four cysteine residues, scientists divided the chemokines into four main subfamilies: CXC, CC, CX3C, and XC. Among them, the C chemokine protein is different from all other chemokines in that it has only two cysteine. One is at the N-terminal cysteine and the other is at the downstream half. Typical representatives of this subgroup are XCL1 (lymphokine-α) and XCL2 (lymphokine-β).