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Cardiotoxicity Service Based on Fluorescent Imaging and Microinjection Techniques

STEMart offers an advanced Cardiotoxicity Service utilizing fluorescent imaging and microinjection techniques to assess the impact of therapeutic compounds on cardiac function in preclinical models. Our laboratory is equipped with high-resolution fluorescent imaging systems and precise microinjection tools, allowing us to deliver compounds directly into the cardiovascular system of animal models such as zebrafish embryos. These techniques enable real-time visualization and assessment of heart development and function, making them ideal for early-stage cardiotoxicity screening.

Fluorescent imaging allows researchers to track cellular and molecular processes in real-time, providing detailed insights into how compounds affect heart structure and function. Paired with microinjection techniques, which allow precise delivery of test compounds or genetic material, this service is particularly valuable in pharmacology, toxicology, and drug development. These methods are widely used to evaluate cardiotoxic effects during drug development and to identify potential risks associated with therapeutic candidates.

Leveraging our expertise in cardiovascular research and cutting-edge imaging technologies, we offer a comprehensive suite of cardiotoxicity services. Whether you are investigating early developmental impacts or studying compound-induced heart failure, our services are designed to provide accurate, reproducible data to support your research and regulatory submissions.

What We Offer

  • In Vivo Cardiotoxicity Assessment

Real-time evaluation of cardiac function in live zebrafish embryos, providing early detection of compound-induced cardiotoxic effects through high-resolution fluorescent imaging.

  • Microinjection of Therapeutic Compounds

Precision microinjection techniques to deliver drugs, chemicals, or genetic materials into the cardiovascular system for targeted cardiotoxicity studies.

  • Developmental Cardiovascular Toxicity Testing

Assessment of the impact of drugs on the developing cardiovascular system, using fluorescent imaging to monitor heart structure and function during early development.

  • Electrophysiology and Heart Rate Monitoring

Monitoring of heart rate and electrical activity in zebrafish embryos to assess the functional impact of compounds on cardiac performance.

  • High-Throughput Cardiotoxicity Screening

Screening multiple compounds in parallel using automated imaging and microinjection systems, ideal for early-stage cardiotoxicity evaluation in drug development.

Why Choose Us

  • High-Resolution Imaging

Our state-of-the-art fluorescent imaging systems offer high-resolution, real-time visualization of cardiac function, ensuring accurate detection of cardiotoxicity.

  • Precision Microinjection

We utilize advanced microinjection techniques for precise delivery of test compounds into cardiovascular tissues, ensuring targeted and reproducible results.

  • Comprehensive Cardiovascular Assessment

Our services cover a wide range of cardiotoxicity parameters, from structural abnormalities to functional impacts on heart rate and rhythm.

Our Resources

Fluorescent Imaging System (Leica DMi8)

This advanced fluorescent imaging system enables high-resolution visualization of cardiac tissues in real-time, providing detailed insights into compound-induced cardiotoxic effects.

Microinjection System (Eppendorf FemtoJet 4i)

The Eppendorf FemtoJet 4i microinjection system allows for precise delivery of compounds into zebrafish embryos, ensuring accurate targeting for cardiotoxicity testing.

Electrophysiology Monitoring System (NPI Electronics ELC-03XS)

Our electrophysiology system records electrical activity and heart rate in zebrafish embryos, providing real-time data on the functional impact of test compounds on cardiac function.

STEMart provides high-quality animal model services tailored to meet the specific needs of our clients. Our team of experienced specialists utilizes cutting-edge equipment and adheres to rigorous quality control protocols, ensuring precise and dependable results. Contact us to learn more about our animal model services and how we can help you achieve your research goals.

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