Cardiovascular Disease Service Based on Aortic Banding Surgery

STEMart offers an advanced Cardiovascular Disease Service utilizing aortic banding surgery to model cardiovascular conditions such as heart failure and hypertension in preclinical research. Aortic banding is a well-established technique used to induce pressure overload in the heart, leading to hypertrophy and heart failure. In our laboratory, this precise surgical model enables the study of cardiac remodeling, disease progression, and therapeutic interventions, providing invaluable insights into cardiovascular disease mechanisms.

Aortic banding involves the constriction of the aorta, which increases the workload on the left ventricle, causing hypertrophy and eventually leading to heart failure. This model is essential for studying the molecular and physiological responses to increased cardiac stress, making it a powerful tool in cardiovascular research. The technique is applied across disciplines such as cardiology, pharmacology, and pathology to evaluate the efficacy of new therapies and to understand the underlying mechanisms of heart disease.

Leveraging our expertise in cardiovascular research and aortic banding techniques, we offer a comprehensive range of services that cater to the study of heart disease progression and therapeutic efficacy. Our services are designed to support drug discovery, biomarker development, and mechanistic studies, providing accurate, reproducible results in preclinical models.

What We Offer

• Aortic Banding Surgery Service

Precise aortic constriction to induce cardiac hypertrophy and heart failure, providing a reliable model for studying cardiovascular diseases and therapeutic responses.

• Cardiac Function Monitoring Service

Comprehensive assessment of heart function using echocardiography and pressure-volume loop analysis, providing detailed insights into cardiac performance post-surgery.

• Therapeutic Intervention Testing Service

Evaluation of pharmacological treatments in the aortic banding model to assess their ability to prevent or reverse cardiac hypertrophy and heart failure.

• Cardiac Biomarker Analysis Service

Measurement of key cardiac biomarkers associated with heart failure, such as BNP and troponin, to monitor disease progression and treatment efficacy.

Why Choose Us

• Precise Surgical Techniques

Our aortic banding procedure is performed with precision, ensuring reproducible and consistent results for cardiovascular disease research.

• Comprehensive Cardiac Monitoring

We provide detailed monitoring of heart function using state-of-the-art imaging and pressure measurement systems, offering valuable data on disease progression.

• Tailored Study Designs

Our services are customizable to meet the specific needs of your research, including drug testing, biomarker discovery, and mechanistic studies.

• Expert Cardiovascular Team

Our team of experienced cardiovascular researchers offers full support throughout your study, from surgery to data analysis, ensuring optimal outcomes.

Our Resources

Echocardiography System (VisualSonics Vevo 3100)

This high-resolution echocardiography system provides non-invasive imaging of heart function, allowing for precise monitoring of cardiac performance following aortic banding surgery.

Pressure-Volume Loop System (Millar Mikro-Tip® Catheter)

The Millar Mikro-Tip catheter system offers detailed pressure-volume analysis, providing real-time data on left ventricular function during and after aortic banding procedures.

Surgical Microscope (Zeiss OPMI Vario)

The Zeiss OPMI Vario surgical microscope enables precise visualization during the aortic banding procedure, ensuring accuracy in vessel constriction and minimizing surgical variability.

STEMart provides high-quality animal model services tailored to meet the specific needs of our clients. Our team of experienced specialists utilizes cutting-edge equipment and adheres to rigorous quality control protocols, ensuring precise and dependable results. Contact us to learn more about our animal model services and how we can help you achieve your research goals.