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Blot system is a rapid protein transfer apparatus which is used to immboilise proteins or nucleic acid separation on a solid membrane support. Blotting is a popular technique used for protein detection and quantitation. It enables user to separate and identify a specific protein of interest from a complex mixture of proteins, such as a cell lysate. With applications in diagnostics, biotechnology, molecular biology, proteomics, and much more, blots are widely relied upon to evaluate levels of protein expression in cells, as well changes in size and other properties. There are four types of blot systems: the modular electroblotters, tank transfers systems, semi-dry transfer systems and microfiltration (dot and slot blotting).