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Cell culture bioreactors can be used for the large-scale cultivation of various cell types, including mammalian cell lines, stem cells, and insect cells. Cell culture in bioreactors has a wide range of applications, including cell and gene therapy development, and the production of antibodies, vaccines, and viral vectors. The cultivation of human and animal cells in stirred-tank bioreactors offers many benefits: cell culture in stirred-tank bioreactors is scalable, from research scale in the milliliter range to thousands of liters. High yields can be achieved, and batch-to-batch variability can be kept low.