Combustion Oxidation and Non-Dispersive Infrared Absorption Method

The Combustion Oxidation and Non-Dispersive Infrared (NDIR) Absorption Method is a vital technique for determining the Total Organic Carbon (TOC) content in water used for pharmaceutical purposes. In this method, organic carbon in the water sample is oxidized through combustion, converting the carbon content to carbon dioxide (CO2). The released CO2 is then quantified using NDIR spectroscopy, which measures the absorption of infrared light by the CO2 molecules. This allows for precise and highly sensitive TOC analysis, ensuring that pharmaceutical-grade water meets stringent quality standards by detecting even trace amounts of organic impurities. The method is a cornerstone of quality control in pharmaceutical manufacturing, where water purity is critical to product safety and efficacy.