Determination of Total Organic Carbon in Water for Pharmaceutical Use

The determination of Total Organic Carbon (TOC) in water for pharmaceutical use is a critical analytical technique that assesses the presence of carbon compounds in water samples. TOC analysis is essential in pharmaceutical manufacturing to ensure the quality and compliance of water used in drug production processes. Various methods are employed to measure TOC, including combustion oxidation and non-dispersive infrared absorption, wet chemical oxidation, supercritical water oxidation, ultraviolet oxidation, and conductance technology. These methods help pharmaceutical companies monitor and control water quality, ensuring that it meets the stringent standards required for drug production, where even trace levels of organic contaminants can impact product safety and efficacy. TOC analysis plays a pivotal role in maintaining pharmaceutical water systems' reliability and consistency.