Differential Scanning Calorimetry (DSC) Technology

Differential Scanning Calorimetry (DSC) is an analysis technique used to characterize the stability of a protein or other biomolecule directly in its native form. As well as being used to characterize the thermal properties of a material, a differential scanning calorimeter is used to determine the temperature at which particular phase transitions occur, including glass transition temperature, fusion and crystallization events. It does this by measuring the heat change associated with the molecule’s thermal denaturation when heated at a constant rate. There is a wide range of applications for differential scanning calorimetry across chemistry, biochemistry, cell biology, pharmacology, nanoscience, and other fields. DSC is considered an accurate, simple and user-friendly technique and, consequently, it is probably the most popular thermal analysis method.