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Immunoaffinity chromatography is a separation and purification technology based on interactions between membrane antigens and immobilized antibodies or membrane receptors and their ligands. It is column-based, which means that the solution is flowed through a column and eluted at the other end. The column is pre-functionalized with the capture antibody or antigen. Immunoaffinity chromatography is a valuable tool in the field of molecular separation and purification. Its exceptional specificity and compatibility with other chromatographic methods make it an indispensable technique for researchers and industries involved in biotechnology, pharmaceuticals, and clinical diagnostics.