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Biomolecular interactions underpin most processes inside the cell. While some proteins function independently, most proteins are only active in complex forms. This means their associations with other biomolecules, such as metals, lipids, proteins, and nucleic acids, are extremely important. Biomolecular interaction analysis is at the center of attention in a wide range of disciplines, from biochemistry and biotechnology to medicine. Being the focus of both basic sciences and in applied research and development, the overall ambition of the interaction studies ranges from purely gaining increased knowledge and understanding of biological systems and functions, to applying and using the gained knowledge in the design of pharmaceuticals, bio-inspired sensors and technology with an aim to improve our quality of live.