Matrix Assisted Laser Desorption Ionisation-Time of Flight (MALDI-TOF) Mass Spectrometry

Matrix assisted laser desorption ionisation-time of flight (MALDI-TOF) mass spectrometry is a new soft ionizing biomass spectrometry technology developed in recent years. The principle is as follows: in a very small area and a very short time interval (ns order of magnitude), the laser delivers high-intensity pulse energy to the sample under test, causing it to desorption and ionize instantaneously without thermal decomposition. MALDI is a mass spectrometry ionization method for direct evaporation and ionization of non-volatile samples. The technology has been widely used in the analysis of polypeptides, proteins, oligonucleotides and oligosaccharides.