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Orthopaedics is the medical specialty that focuses on injuries and diseases of your body's musculoskeletal system. This complex system, which includes your bones, joints, ligaments, tendons, muscles, and nerves. Orthopedic diseases are one of the most common diseases in clinical practice, and animal models of orthopedic diseases have become one of the most used animal models. In vivo animal models are frequently used in orthopedic and trauma research. Animal models are essential not only to evaluate pathological bone but also to study tissue response, biocompatibility and mechanical properties, especially when it comes to implant materials.