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Histological staining is the gold standard for tissue examination in clinical pathology and life-science research, which visualizes the tissue and cellular structures using chromatic dyes or fluorescence labels to aid the microscopic assessment of tissue. Each stain exists to highlight an important feature or component within a tissue type. The benefit of using a special stain is that it can highlight the specific protein very well. However, because of its specificity, the other structures will not be seen. Different staining systems meet different needs. Each laboratory can be equipped with a suitable staining system according to its individual requirements. Pre-owned histology equipment can be used to prepare and examine tissues while managing budget constraints effectively.