Cryo-CLEM Service Based on Leica Cryo CLEM System

STEMart offers advanced Cryo-Correlative Light and Electron Microscopy (Cryo-CLEM) services using the Leica Cryo CLEM System. This cutting-edge technology enables the integration of fluorescence microscopy with high-resolution electron microscopy in frozen samples, ensuring the preservation of native biological structures. Our laboratory is equipped with industry-leading instruments, allowing us to perform detailed imaging and analysis at cryogenic temperatures with minimal sample distortion.

Cryo-CLEM combines cryogenic light microscopy with cryo-electron microscopy (cryo-EM), enabling researchers to locate fluorescently labeled structures and then analyze them in detail using electron microscopy. This technique is highly beneficial for studying cells, proteins, and organelles at both the molecular and structural levels, with applications in fields such as structural biology, cell biology, and neurobiology.

Leveraging our advanced Leica Cryo CLEM System, STEMart offers a range of cryo-imaging services to meet the demands of researchers in various disciplines. Our specialized services allow researchers to visualize frozen samples in their near-native state, enabling accurate and meaningful analysis across multiple fields of study.

What We Offer

• Cryo-CLEM Imaging Service

Integration of cryogenic fluorescence and electron microscopy for precise localization and structural analysis of frozen samples.

• Fluorescence and Electron Microscopy Correlation

Correlate fluorescent markers with ultrastructural data to identify and analyze specific regions of interest.

• Ultrastructure Mapping in Frozen Samples

Provides high-resolution mapping of biological samples in their cryo-preserved state, ensuring minimal structural distortion.

• High-Resolution Cryo-Electron Microscopy

Detailed imaging of cellular structures and macromolecules at cryogenic temperatures, maintaining the native state of samples.

Why Choose Us

• Preservation of Native Structures

Cryo-preservation ensures that biological structures remain intact, allowing for accurate analysis without artifacts introduced by chemical fixation.

• Comprehensive Correlative Imaging

Our services seamlessly integrate fluorescence microscopy with electron microscopy, providing both functional and structural insights.

• Expert Imaging and Analysis Team

Our experienced team specializes in cryo-imaging and can develop tailored workflows to suit your research requirements.

Our Equipment

Leica Cryo CLEM System

The Leica Cryo CLEM System enables the combination of cryogenic light and electron microscopy, preserving biological samples in their native state. This system offers precise fluorescence and electron microscopy correlation, making it ideal for detailed studies of cryo-preserved samples. It is designed for high-resolution imaging and minimal sample distortion, ensuring accurate analysis.

STEMart provides high-quality advanced microscopy services tailored to meet the specific needs of our clients. Our experienced specialists use advanced equipment and follow strict quality control measures to ensure accurate and reliable results. Contact us to learn more about our advanced microscopy services and how we can help you achieve your research goals.