Cryo-Correlative Workflow Service Based on Thermo Fisher Krios and CorrSight

STEMart provides a comprehensive Cryo-Correlative Workflow Service using the advanced Thermo Fisher Krios and CorrSight systems. These powerful instruments allow for the seamless integration of cryogenic light microscopy and high-resolution cryo-electron microscopy, offering researchers unmatched precision in imaging biological samples at cryogenic temperatures. This workflow is ideal for capturing the dynamic range of biological activities in their native states.

The Thermo Fisher Krios Cryo-EM, combined with the CorrSight system, enables the correlation between fluorescence and electron microscopy at cryogenic temperatures. This method is highly useful in structural biology, neuroscience, and cell biology, where both functional and structural information are critical for a complete understanding of biological processes. The use of both systems allows researchers to achieve superior spatial resolution while maintaining the native state of their samples.

Leveraging our cutting-edge cryo-correlative workflow, STEMart offers a range of cryo-imaging services that provide insights into complex biological structures. Our expert team ensures efficient workflow coordination, helping researchers acquire high-quality, correlative datasets that combine the strengths of both cryogenic fluorescence and electron microscopy.

What We Offer

• Cryo-CLEM Workflow Service

Comprehensive correlation of cryogenic light microscopy and cryo-electron microscopy for detailed biological insights.

• Fluorescence to EM Correlation

Efficient integration of fluorescence data with electron microscopy for high-precision localization and structural analysis.

• Cryo-EM 3D Reconstruction

Obtain detailed three-dimensional reconstructions of biological structures with cryo-electron tomography.

• High-Resolution Imaging

Capture high-resolution images of cryogenically preserved samples using the Thermo Fisher Krios Cryo-EM.

• Automated Cryo Sample Handling

Automated workflows that ensure minimal sample distortion and optimal cryo-preservation, streamlining the entire imaging process.

Why Choose Us

• Seamless Workflow Integration

Our Thermo Fisher Krios and CorrSight workflow ensures seamless correlation between fluorescence and electron microscopy.

• Preservation of Native Sample States

Cryogenic conditions preserve biological structures in their native state, ensuring accurate and artifact-free analysis.

• Expert Cryo-Imaging Team

Our experienced imaging specialists provide expert support in handling and analyzing cryogenically preserved samples.

• High-Throughput Cryo-EM

Equipped with automated data collection features, we offer high-throughput cryo-EM analysis with rapid turnaround times.

Our Equipment

Thermo Fisher Krios Cryo-EM

The Thermo Fisher Krios Cryo-EM is designed for high-resolution imaging of biological specimens in cryogenic conditions. It features advanced automation, high throughput, and superior resolution, enabling researchers to acquire detailed structural data at the molecular and cellular levels. Its cryo-tomography capabilities provide in-depth 3D visualizations.

Thermo Fisher CorrSight

The Thermo Fisher CorrSight is a high-end correlative microscopy platform that bridges fluorescence microscopy with electron microscopy. This system provides high-precision localization of fluorescent signals and facilitates the seamless transition to high-resolution cryo-electron microscopy, ensuring precise correlation of functional and structural data.

STEMart provides high-quality advanced microscopy services tailored to meet the specific needs of our clients. Our experienced specialists use advanced equipment and follow strict quality control measures to ensure accurate and reliable results. Contact us to learn more about our advanced microscopy services and how we can help you achieve your research goals.