Determination of Imbalances of chromosome 17 in medulloblastomas by Fluorescence in situ hybridisation (FISH) (CAT#: STEM-MB-1221-WXH)

Introduction

Medulloblastomas make up more than 90% of cases of central nervous system (CNS) primitive neuroectodermal tumours, which are the most common CNS tumours in childhood.
The analysis of genetic abnormalities has been one focus of research on the biology of primitive neuroectodermal tumours. Cytogenetic studies of medulloblastoma have identified several non-random chromosomal aberrations in a high proportion of cases. Of these, isochromosome 17q (i(17q)) is the most common, occurring in a third of successfully karyotyped cases. Microsatellite analysis has corroborated the existence of chromosome 17 abnormalities by documenting the loss of heterozygosity (LOH) on 17p.