Determination of Melting Point of 2,4,5-Triphenyl Imidazole Derivatives by Open Capillary Method (CAT#: STEM-PPA-0072-YJL)

Introduction

Imidazoles are a class of heterocyclic compounds that contain nitrogen and are currently under intensive focus due to their wide range of applications. Synthetic study of imidazole units is very important due to their potent biological activity and synthetic utility. Imidazoles are an important class of heterocycles being the core fragment of different natural products and biological systems. Compounds containing imidazole moiety have many pharmacological properties and play important roles in biochemical processes. The potency and wide applicability of the imidazole pharmacophore can be attributed to its hydrogen bond donor-acceptor capability as well as its high affinity for metals (e.g., Zn, Fe, Mg), which are present in many protein active sites3b. Naturally occurring substituted imidazoles, as well as synthetic derivatives thereof, exhibit wide ranges of biological activities, making them attractive compounds for organic chemists.